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Thesis

Characterising differences between the regenerative and non-regenerative immune response in the Astyanax mexicanus

Abstract:

The human heart cannot regenerate following myocardial infarction and instead forms a fibrotic scar that impairs cardiac function and can lead to heart failure. Cardiac regeneration aims to treat the injured heart by stimulating the heart to repair itself. The Astyanax mexicanus is a uniquely suited model of cardiac regeneration as it comprises two closely related populations: (1) the ‘regenerative’ surface (SF) population and (2) the ‘non-regenerative’ Pachόn (PF) cave population. The imm...

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More by this author
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
New College
Role:
Author
ORCID:
0000-0002-7829-7823

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Research group:
IDRM
Oxford college:
St Antony's College
Role:
Supervisor
ORCID:
0000-0001-6624-3038
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Supervisor
ORCID:
0000-0002-8046-1688
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Examiner
ORCID:
0000-0002-0934-3662
More from this funder
Name:
British Heart Foundation
Grant:
FS/17/68/33478
Programme:
4-year BHF PhD programme in Cardiovascular Science
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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