Journal article icon

Journal article

The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy.

Abstract:

DNA damaging agents such as radiotherapy and gemcitabine are frequently used for the treatment of pancreatic cancer. However, these treatments typically provide only modest benefit. Improving the low survival rate for pancreatic cancer patients therefore remains a major challenge in oncology. Inhibition of the key DNA damage response kinase ATR has been suggested as an attractive approach for sensitization of tumor cells to DNA damaging agents, but specific ATR inhibitors have remained elusiv...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.4161/cbt.21093

Authors


Reaper, PM More by this author
Charlton, PA More by this author
Pollard, JR More by this author
Expand authors...
Journal:
Cancer biology and therapy
Volume:
13
Issue:
11
Pages:
1072-1081
Publication date:
2012-09-05
DOI:
EISSN:
1555-8576
ISSN:
1538-4047
URN:
uuid:e4b7ad28-dcb6-4715-bfb2-df0ee1dd5ff2
Source identifiers:
349848
Local pid:
pubs:349848

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP