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Structural stability of human protein tyrosine phosphatase ρ catalytic domain: effect of point mutations.

Abstract:

Protein tyrosine phosphatase ρ (PTPρ) belongs to the classical receptor type IIB family of protein tyrosine phosphatase, the most frequently mutated tyrosine phosphatase in human cancer. There are evidences to suggest that PTPρ may act as a tumor suppressor gene and dysregulation of Tyr phosphorylation can be observed in diverse diseases, such as diabetes, immune deficiencies and cancer. PTPρ variants in the catalytic domain have been identified in cancer tissues. These natural variants are n...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0032555

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Department of Biochemical Sciences More from this funder
Sapienza - Università di Roma More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
7
Issue:
2
Article number:
e32555
Publication date:
2012-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
320693
Language:
English
Keywords:
UUID:
uuid:e4b3b3a3-66dc-4534-aad8-68f0f4baaed6
Local pid:
pubs:320693
Deposit date:
2012-12-19

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