Journal article
Structural stability of human protein tyrosine phosphatase ρ catalytic domain: effect of point mutations.
- Abstract:
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Protein tyrosine phosphatase ρ (PTPρ) belongs to the classical receptor type IIB family of protein tyrosine phosphatase, the most frequently mutated tyrosine phosphatase in human cancer. There are evidences to suggest that PTPρ may act as a tumor suppressor gene and dysregulation of Tyr phosphorylation can be observed in diverse diseases, such as diabetes, immune deficiencies and cancer. PTPρ variants in the catalytic domain have been identified in cancer tissues. These natural variants are n...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 705.1KB)
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- Publisher copy:
- 10.1371/journal.pone.0032555
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Authors
Funding
Department of Biochemical Sciences
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Sapienza - Università di Roma
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 7
- Issue:
- 2
- Article number:
- e32555
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- Source identifiers:
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320693
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:e4b3b3a3-66dc-4534-aad8-68f0f4baaed6
- Local pid:
- pubs:320693
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Pasquo et al
- Copyright date:
- 2012
- Notes:
- Copyright 2012 Pasquo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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