Potassium channel regulation.

Journal article

The sulphonylurea receptor (SUR) is a member of the ATP-binding cassette (ABC) family of membrane proteins. It functions as the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which comprises SUR and Kir6.x proteins. Here, we review data demonstrating functional differences between the two nucleotide binding domains (NBDs) of SUR1. In addition, to explain the structural basis of these functional differences, we have constructed a molecular model of the NBD dimer of human SUR...

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Authors: Campbell, J; Sansom, MS; Ashcroft, F

• Journal: EMBO reports
• Volume: 4
• Issue: 11
• Pages: 1038-1042
• Publication date: 2003-11-01
• DOI: 10.1038/sj.embor.7400003
• EISSN: 1469-3178
• ISSN: 1469-221X
• Language: English
• Keywords: ATP-Binding Cassette Transporters; Humans; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Amino Acid Sequence; Molecular Sequence Data; Mutation; Nucleotides; Protein Structure, Tertiary; Genetic Diseases, Inborn; Protein Binding