- Abstract:
-
The development and maintenance of memory B cells (MBC) is dependent on germinal centres (GC) with follicular dendritic cell (FDC) networks. We have previously shown that FDC networks within GC of the spleen express a novel ligand for CD38 and that the administration of soluble CD38 induces an expansion of these cellular structures. We therefore used adoptive transfer studies to investigate whether the expansion of FDC networks with soluble CD38 affected the generation and maintenance of anti...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1365-2567.2008.02914.x
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- Journal:
- Immunology
- Volume:
- 125
- Issue:
- 1
- Pages:
- 14-20
- Publication date:
- 2008-09-05
- DOI:
- EISSN:
-
1365-2567
- ISSN:
-
0019-2805
- URN:
-
uuid:e47d9d65-b9f4-4384-b7a1-4fb969ebcfbc
- Source identifiers:
-
6797
- Local pid:
- pubs:6797
- Copyright date:
- 2008
Journal article
Soluble CD38 significantly prolongs the lifespan of memory B-cell responses.
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