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Journal article

Soluble CD38 significantly prolongs the lifespan of memory B-cell responses.

Abstract:

The development and maintenance of memory B cells (MBC) is dependent on germinal centres (GC) with follicular dendritic cell (FDC) networks. We have previously shown that FDC networks within GC of the spleen express a novel ligand for CD38 and that the administration of soluble CD38 induces an expansion of these cellular structures. We therefore used adoptive transfer studies to investigate whether the expansion of FDC networks with soluble CD38 affected the generation and maintenance of anti...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Immunology
Volume:
125
Issue:
1
Pages:
14-20
Publication date:
2008-09-05
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:e47d9d65-b9f4-4384-b7a1-4fb969ebcfbc
Source identifiers:
6797
Local pid:
pubs:6797

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