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Expression and function of the chemokine receptor CCR7 in thyroid carcinomas.

Abstract:

The chemokine receptor CCR7 plays a critical role in lymphocyte and dendritic cell trafficking into and within lymph nodes, the preferential metastatic site for papillary (PTC) and medullary (MTC) thyroid carcinomas. In order to determine a possible role for CCR7 in mediating the metastatic behaviour of thyroid carcinomas, we analysed its expression in normal and tumoral thyroid tissues of different histotypes and studied the in vitro effects of its activation by the CCR7 ligand, CCL21. Using...

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Publisher copy:
10.1677/joe.1.06688

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Journal:
The Journal of endocrinology
Volume:
191
Issue:
1
Pages:
229-238
Publication date:
2006-10-05
DOI:
EISSN:
1479-6805
ISSN:
0022-0795
URN:
uuid:e47aae96-2ea3-44e6-aeee-e61f2322cb13
Source identifiers:
428942
Local pid:
pubs:428942

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