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Journal article

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.

Abstract:

Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that plays a crucial role in mediating cellular responses to oxygen. Oxygen availability influences multiple steps in HIF activation and recent studies have indicated that at least two steps in this process are governed by a novel mode of signal transduction involving enzymatic hydroxylation of specific amino acid residues in HIF-alpha subunits by a series of 2-oxoglutarate (2-OG)-dependent oxygenases. These enzymes are no...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.00655

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Role:
Author
Journal:
Journal of cell science
Volume:
116
Issue:
Pt 15
Pages:
3041-3049
Publication date:
2003-08-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:e46e12d7-96a7-4586-b8db-a15a4f7660f1
Source identifiers:
11847
Local pid:
pubs:11847

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