- Abstract:
-
Squamous cell carcinoma (SCC) is highly malignant and refractory to therapy. The majority of existing mouse SCC models involve multiple gene mutations. Very few mouse models of spontaneous SCC have been generated by a single gene deletion. Here we report a haploinsufficient SCC mouse model in which exon 3 of the Tp53BP2 gene (a p53 binding protein) was deleted in one allele in a BALB/c genetic background. Tp53BP2 encodes ASPP2 (ankyrin repeats, SH3 domain and protein rich region containing pr...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.1309362110
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 110
- Issue:
- 44
- Pages:
- 17969-17974
- Publication date:
- 2013-10-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:e4668a2b-52ab-4b35-b907-28fd22f2bb58
- Source identifiers:
-
434204
- Local pid:
- pubs:434204
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63.
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