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Journal article

Translocation portals for the substrates and products of a viral transcription complex: the bluetongue virus core.

Abstract:

The bluetongue virus core is a molecular machine that simultaneously and repeatedly transcribes mRNA from 10 segments of viral double-stranded RNA, packaged in a liquid crystalline array. To determine how the logistical problems of transcription within a sealed shell are solved, core crystals were soaked with various ligands and analysed by X-ray crystallography. Mg(2+) ions produce a slight expansion of the capsid around the 5-fold axes. Oligonucleotide soaks demonstrate that the 5-fold pore...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/20.24.7229

Authors


Diprose, JM More by this author
Burroughs, JN More by this author
Sutton, GC More by this author
Goldsmith, A More by this author
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Journal:
The EMBO journal
Volume:
20
Issue:
24
Pages:
7229-7239
Publication date:
2001-12-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:e45ca47d-38ad-49af-a60a-9550a71c88d6
Source identifiers:
1787
Local pid:
pubs:1787

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