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Localization of the fragile X mental retardation 2 (FMR2) protein in mammalian brain.

Abstract:

The transcriptional silencing of the FMR2 gene has been implicated in FRAXE mental retardation. FRAXE individuals have been shown to exhibit learning deficits, including speech delay, reading and writing problems. FMR2 encodes a large protein of 1311 amino acids and is a member of a gene family encoding proline-serine-rich proteins that have properties of nuclear transcription factors. To characterize the expression of the fragile X mental retardation 2 (FMR2) protein, polyclonal antibodies w...

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Publication status:
Published

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Authors


Miller, WJ More by this author
Skinner, JA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
The European journal of neuroscience
Volume:
12
Issue:
1
Pages:
381-384
Publication date:
2000-01-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:e44c1e41-f280-4c46-b955-94d45941d834
Source identifiers:
106287
Local pid:
pubs:106287

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