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Distribution and diversity of the haemoglobin-haptoglobin iron-acquisition systems in pathogenic and non-pathogenic Neisseria.

Abstract:

A new generation of vaccines containing multiple protein components that aim to provide broad protection against serogroup B meningococci has been developed. One candidate, 4CMenB (4 Component MenB), has been approved by the European Medicines Agency, but is predicted to provide at most 70-80 % strain coverage; hence there is a need for second-generation vaccines that achieve higher levels of coverage. Prior knowledge of the diversity of potential protein vaccine components is a key step in v...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1099/mic.0.068874-0

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
Wellcome Trust More from this funder
University of Leicester More from this funder
University of Manchester More from this funder
University of Oxford More from this funder
Publisher:
Microbiology Society Publisher's website
Journal:
Microbiology (Reading, England) Journal website
Volume:
159
Issue:
Pt 9
Pages:
1920-1930
Publication date:
2013-09-05
DOI:
EISSN:
1465-2080
ISSN:
1350-0872
URN:
uuid:e448bf0e-dee2-40b1-9f0a-1a18d9232054
Source identifiers:
411024
Local pid:
pubs:411024

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