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Distribution and diversity of the haemoglobin-haptoglobin iron-acquisition systems in pathogenic and non-pathogenic Neisseria.

Abstract:

A new generation of vaccines containing multiple protein components that aim to provide broad protection against serogroup B meningococci has been developed. One candidate, 4CMenB (4 Component MenB), has been approved by the European Medicines Agency, but is predicted to provide at most 70-80 % strain coverage; hence there is a need for second-generation vaccines that achieve higher levels of coverage. Prior knowledge of the diversity of potential protein vaccine components is a key step in v...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1099/mic.0.068874-0

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Derrick, JP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Bayliss, CD More by this author
Wellcome Trust More from this funder
University of Leicester More from this funder
University of Manchester More from this funder
University of Oxford More from this funder
Publisher:
Microbiology Society Publisher's website
Journal:
Microbiology (Reading, England) Journal website
Volume:
159
Issue:
Pt 9
Pages:
1920-1930
Publication date:
2013-09-05
DOI:
EISSN:
1465-2080
ISSN:
1350-0872
URN:
uuid:e448bf0e-dee2-40b1-9f0a-1a18d9232054
Source identifiers:
411024
Local pid:
pubs:411024

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