Journal article icon

Journal article

Simulating Drug-Induced Effects on the Heart: From Ion Channel to Body Surface Electrocardiogram

Abstract:

The electrocardiogram (ECG) is widely used as a clinical tool for the evaluation of cardiac conditions caused by drugs, mutations and diseases. However, the ionic basis underlying changes in the ECG are often unclear. In the present study, we present a computational model of the human ECG capable of representing drug-induced effects from the ionic to the surface potential level. Bidomain simulations are conducted to simulate the electrophysiological activity of the heart and extracellular pot...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Zemzemi, N More by this author
Bernabeu, MO More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science, BHF Centre of Research Excellence
Journal:
FUNCTIONAL IMAGING AND MODELING OF THE HEART
Volume:
6666
Pages:
259-266
Publication date:
2011
DOI:
EISSN:
1611-3349
ISSN:
0302-9743
URN:
uuid:e4482dee-1a80-475e-8a2f-155bdc447c9e
Source identifiers:
304070
Local pid:
pubs:304070
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP