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Journal article

Magnetization transfer ratio may be a surrogate of spongiform change in human prion diseases.

Abstract:

Human prion diseases are fatal neurodegenerative disorders caused by misfolding of the prion protein. There are no useful biomarkers of disease progression. Cerebral cortex spongiform change, one of the classical pathological features of prion disease, resolves in prion-infected transgenic mice following prion protein gene knockout. We investigated the cross-sectional, longitudinal and post-mortem cerebral magnetization transfer ratios as a surrogate for prion disease pathology. Twenty-three ...

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Publication status:
Published

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Publisher copy:
10.1093/brain/awq243

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Journal:
Brain : a journal of neurology
Volume:
133
Issue:
10
Pages:
3058-3068
Publication date:
2010-10-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:e446a406-6014-4015-a221-0b7dc9efa4aa
Source identifiers:
422616
Local pid:
pubs:422616

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