- Abstract:
-
Human prion diseases are fatal neurodegenerative disorders caused by misfolding of the prion protein. There are no useful biomarkers of disease progression. Cerebral cortex spongiform change, one of the classical pathological features of prion disease, resolves in prion-infected transgenic mice following prion protein gene knockout. We investigated the cross-sectional, longitudinal and post-mortem cerebral magnetization transfer ratios as a surrogate for prion disease pathology. Twenty-three ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/brain/awq243
-
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- Journal:
- Brain : a journal of neurology
- Volume:
- 133
- Issue:
- 10
- Pages:
- 3058-3068
- Publication date:
- 2010-10-05
- DOI:
- EISSN:
-
1460-2156
- ISSN:
-
0006-8950
- URN:
-
uuid:e446a406-6014-4015-a221-0b7dc9efa4aa
- Source identifiers:
-
422616
- Local pid:
- pubs:422616
- Copyright date:
- 2010
Journal article
Magnetization transfer ratio may be a surrogate of spongiform change in human prion diseases.
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