Journal article
Functional interplay between E2F7 and ribosomal rRNA gene transcription regulates protein synthesis
- Abstract:
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A prerequisite for protein synthesis is the transcription of ribosomal rRNA genes by RNA polymerase I (Pol I), which controls ribosome biogenesis. UBF (upstream binding factor) is one of the main Pol I transcription factors located in the nucleolus that activates rRNA gene transcription. E2F7 is an atypical E2F family member that acts as a transcriptional repressor of E2F target genes, and thereby contributes to cell cycle arrest. Here, we describe an unexpected role for E2F7 in regulating rR...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.5MB, Terms of use)
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- Publisher copy:
- 10.1038/s41419-018-0529-6
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Bibliographic Details
- Publisher:
- Nature Publishing Group
- Journal:
- Cell Death and Disease More from this journal
- Volume:
- 9
- Article number:
- 577
- Publication date:
- 2018-05-14
- Acceptance date:
- 2018-03-23
- DOI:
- ISSN:
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2041-4889
- Pmid:
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29760477
Item Description
- Language:
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English
- Pubs id:
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pubs:848099
- UUID:
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uuid:e444dfb7-2149-46b3-930d-f5ba21ac1551
- Local pid:
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pubs:848099
- Source identifiers:
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848099
- Deposit date:
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2018-06-14
Terms of use
- Copyright holder:
- © Coutts, et al 2018
- Copyright date:
- 2018
- Notes:
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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