Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors.

Journal article

One of the defining biochemical features of Cushing's disease is a relative insensitivity to glucocorticoid (GC) feedback, but an analysis of the GC receptor has failed to detect any major abnormalities. However, two isoenzymes of 11 beta-hydroxysteroid dehydrogenase (11 beta HSD), either by converting cortisone (E) to cortisol (F) (type 1) or conversely by converting F to E (type 2), play an important prereceptor role in regulating corticosteroid hormone action at several sites. 11 beta HSD1...

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Authors: Korbonits, M; Bujalska, I; Shimojo, M; Nobes, J; Jordan, S

• Publication status: Published
• Journal: Journal of clinical endocrinology and metabolism
• Volume: 86
• Issue: 6
• Pages: 2728-2733
• Publication date: 2001-06-01
• DOI: 10.1210/jc.86.6.2728
• EISSN: 1945-7197
• ISSN: 0021-972X
• Language: English
• Keywords: Reference Values; Middle Aged; Adult; Hydroxysteroid Dehydrogenases; Male; 11-beta-Hydroxysteroid Dehydrogenases; Adolescent; Adrenocorticotropic Hormone; Aged; Tissue Distribution; Isoenzymes; Pituitary Neoplasms; Aged, 80 and over; Female; Humans; Fluorescent Antibody Technique