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Journal article

Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells.

Abstract:

Microfluorimetric and patch-clamp techniques have been combined to determine the relationship between changes in mitochondrial metabolism, the activity of KATP channels and changes in intracellular free calcium concentration ([Ca2+]i) in isolated pancreatic beta-cells in response to glucose, ketoisocaproic acid (KIC) and the electron donor couple tetramethyl p-phenylenediamine (TMPD) and ascorbate. Exposure of cells to 20 mM glucose raised NAD(P)H autofluorescence after a delay of 28 +/- 1 s ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
The Biochemical journal
Volume:
294 ( Pt 1)
Pages:
35-42
Publication date:
1993-08-05
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:e438641c-75b4-457f-aa4c-cf8981d0af0b
Source identifiers:
115092
Local pid:
pubs:115092

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