Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells.

Duchen, MR; Smith, PA; Ashcroft, FM

Abstract:

Microfluorimetric and patch-clamp techniques have been combined to determine the relationship between changes in mitochondrial metabolism, the activity of KATP channels and changes in intracellular free calcium concentration ([Ca2+]i) in isolated pancreatic beta-cells in response to glucose, ketoisocaproic acid (KIC) and the electron donor couple tetramethyl p-phenylenediamine (TMPD) and ascorbate. Exposure of cells to 20 mM glucose raised NAD(P)H autofluorescence after a delay of 28 +/- 1 s ...

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APA Style

Duchen, M. R., Smith, P. A., & Ashcroft, F. M. (1993). Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells. The Biochemical Journal, 294 ( Pt 1), 35–42.

MLA Style

Duchen, M. R., et al. “Substrate-Dependent Changes in Mitochondrial Function, Intracellular Free Calcium Concentration and Membrane Channels in Pancreatic Beta-Cells.” The Biochemical Journal, vol. 294 ( Pt 1), 1993, pp. 35–42.

Chicago Style

Duchen, MR, PA Smith, and FM Ashcroft. 1993. “Substrate-Dependent Changes in Mitochondrial Function, Intracellular Free Calcium Concentration and Membrane Channels in Pancreatic Beta-Cells.” The Biochemical Journal 294 ( Pt 1): 35–42.
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