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Thesis

A novel approach to the synthesis of the FG fragment of pectenotoxin-4

Abstract:

The cobalt-catalysed oxidative cyclisation of 5-hydroxy alkenes has been demonstrated to be a powerful synthetic tool for the formation of trans-THFs with excellent diastereoselectivity. This thesis describes the utilisation of this methodology in the synthesis of the FG fragment of pectenotoxin-4, allowing the scope of the reaction to be further explored.

Introduction: This section introduces the pectenotoxins, a family of structurally complex closed-chain polyether macrolides with ...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Prof. Timothy J Donohoe
Oxford college:
Lincoln College
Role:
Author

Contributors

Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:e434af14-cc0d-4ecf-b60e-2ed635e48fb8
Local pid:
ora:6479
Deposit date:
2012-10-02

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