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Tracking the incidence and risk factors for SARS-CoV-2 infection using historical maternal booking serum samples

Abstract:

The early transmission dynamics of SARS-CoV-2 in the UK are unknown but their investigation is critical to aid future pandemic planning. We tested over 11,000 anonymised, stored historic antenatal serum samples, given at two north-west London NHS trusts in 2019 and 2020, for total antibody to SARS-CoV-2 receptor binding domain (anti-RBD). Estimated prevalence of seroreactivity increased from 1% prior to mid-February 2020 to 17% in September 2020. Our results show higher prevalence of seroreac...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0273966

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Role:
Author
ORCID:
0000-0003-1886-6358
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
17
Issue:
9
Article number:
e0273966
Publication date:
2022-09-02
Acceptance date:
2022-08-19
DOI:
EISSN:
1932-6203
Pmid:
36054212
Language:
English
Keywords:
Pubs id:
1277576
Local pid:
pubs:1277576
Deposit date:
2022-10-05

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