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Alphaviral vector-transduced dendritic cells are successful therapeutic vaccines against neu-overexpressing tumors in wild-type mice.

Abstract:

While dendritic cell (DC) vaccines can protect hosts from tumor challenge, their ability to effectively inhibit the growth of established tumors remains indeterminate. Previously, we have shown that human DCs transduced with Venezuelan equine encephalitis virus replicon particles (VRPs) were potent stimulators of antigen-specific T cells in vitro. Therefore, we investigated the ability of VRP-transduced DCs (VRP-DCs) to induce therapeutic immunity in vivo against tumors overexpressing the neu...

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Authors


Burgents, JE More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Jaffee, EM More by this author
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Journal:
Vaccine
Volume:
25
Issue:
36
Pages:
6604-6612
Publication date:
2007-09-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:e422ac33-3bec-4a0e-9a2d-f675e625cd0b
Source identifiers:
400759
Local pid:
pubs:400759

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