Residual embryonic cells as precursors of a Barrett's-like metaplasia.

Journal article

Barrett's esophagus is an intestine-like metaplasia and precursor of esophageal adenocarcinoma. Triggered by gastroesophageal reflux disease, the origin of this metaplasia remains unknown. p63-deficient mice, which lack squamous epithelia, may model acid-reflux damage. We show here that p63 null embryos rapidly develop intestine-like metaplasia with gene expression profiles similar to Barrett's metaplasia. We track its source to a unique embryonic epithelium that is normally undermined and re...

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Authors: Wang, X; Ouyang, H; Yamamoto, Y; Kumar, P; Wei, T

• Publication status: Published
• Journal: Cell
• Volume: 145
• Issue: 7
• Pages: 1023-1035
• Publication date: 2011-06-01
• DOI: 10.1016/j.cell.2011.05.026
• EISSN: 1097-4172
• ISSN: 0092-8674
• Language: English
• Keywords: Animals; Trans-Activators; Metaplasia; Mice; Gene Expression Profiling; Phosphoproteins; Humans; Esophagus; Barrett Esophagus; Intestine, Small