No evidence for competition between cytotoxic T-lymphocyte responses in HIV-1 infection.

Journal article

Strong competition between cytotoxic T-lymphocytes (CTLs) specific for different epitopes in human immunodeficiency virus (HIV) infection would have important implications for the design of an HIV vaccine. To investigate evidence for this type of competition, we analysed CTL response data from 97 patients with chronic HIV infection who were frequently sampled for up to 96 weeks. For each sample, CTL responses directed against a range of known epitopes in gag, pol and nef were measured using a...

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Authors: Fryer, H; Scherer, A; Oxenius, A; Phillips, R; Mclean, A

• Publication status: Published
• Journal: Proceedings. Biological sciences / The Royal Society
• Volume: 276
• Issue: 1677
• Pages: 4389-4397
• Publication date: 2009-12-01
• DOI: 10.1098/rspb.2009.1232
• EISSN: 1471-2954
• ISSN: 0962-8452
• Language: English
• Keywords: Epitopes, T-Lymphocyte; HIV Infections; Models, Theoretical; T-Lymphocytes, Cytotoxic; HIV-1; Humans; Switzerland; Immunoenzyme Techniques