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Uncoupling VEGFA Functions in Arteriogenesis and Hematopoietic Stem Cell Specification

Abstract:

VEGFA signaling is critical for endothelial and hematopoietic stem cell (HSC) specification. However, blood defects resulting from perturbation of the VEGFA pathway are always accompanied by impaired vascular/arterial development. Because HSCs derive from arterial cells, it is unclear whether VEGFA directly contributes to HSC specification. This is an important question for our understanding of how HSCs are formed and for developing their production in vitro. Through knockdown of the regulato...

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Publisher copy:
10.1016/j.devcel.2012.12.004

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Journal:
Developmental Cell More from this journal
Volume:
24
Issue:
2
Pages:
144-158
Publication date:
2013-01-28
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
Language:
English
Pubs id:
pubs:384737
UUID:
uuid:e3fc702c-3bde-4bf4-960e-c3cd2541f9fc
Local pid:
pubs:384737
Source identifiers:
384737
Deposit date:
2013-11-16

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