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Journal article

A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI.

Abstract:

Human and murine cerebral malaria are associated with elevated levels of cytokines in the brain and adherence of platelets to the microvasculature. Here we demonstrated that the accumulation of platelets in the brain microvasculature can be detected with MRI, using what we believe to be a novel contrast agent, at a time when the pathology is undetectable by conventional MRI. Ligand-induced binding sites (LIBS) on activated platelet glycoprotein IIb/IIIa receptors were detected in the brains o...

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Publication status:
Published

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Publisher copy:
10.1172/jci33314

Authors


von Zur Muhlen, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Wilainam, P More by this author
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Journal:
The Journal of clinical investigation
Volume:
118
Issue:
3
Pages:
1198-1207
Publication date:
2008-03-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:e3eeb965-2905-4d8c-a769-a34ba9e735f7
Source identifiers:
106048
Local pid:
pubs:106048

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