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Journal article

Multiplex allele-specific polymerase chain reaction for detection of isoniazid resistance in Mycobacterium tuberculosis.

Abstract:

SETTING: Pham Ngoc Thach Tuberculosis Reference Hospital, Ho Chi Minh City, Viet Nam. DESIGN: A multiplex allele-specific polymerase chain reaction (MAS-PCR) was developed to detect mutations at the two most common sites responsible for isoniazid (INH) resistance in Mycobacterium tuberculosis: katG315 and inhA-15. The MAS-PCR is able to detect rare mutations at katG315, in addition to katG S315T. Conventional phenotypic proportion drug susceptibility testing on Löwenstein-Jensen media was us...

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Publication status:
Published

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Publisher copy:
10.5588/ijtld.10.0599

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
Journal:
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Volume:
15
Issue:
6
Pages:
799-803
Publication date:
2011-06-05
DOI:
EISSN:
1815-7920
ISSN:
1027-3719
URN:
uuid:e3eeb45a-981e-403d-a00a-d9f6f8663746
Source identifiers:
141431
Local pid:
pubs:141431

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