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Protein inhibitor of NOS1 plays a central role in the regulation of NOS1 activity in human dilated hearts

Abstract:

An essential factor for the production of nitric oxide by nitric oxide synthase 1 (NOS1), major modulator of cardiac function, is the cofactor tetrahydrobiopterin (BH4). BH4 is regulated by GTP cyclohydrolase 1, the rate-limiting enzyme in BH4 biosynthesis which catalyses the formation of dihydroneopterin 3′triphosfate from GTP, producing BH4 after two further steps catalyzed by 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase. However, there are other essential factors involved ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep30902

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Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Pages:
Article: 30902
Publication date:
2016-08-02
DOI:
ISSN:
2045-2322
Pubs id:
pubs:638966
URN:
uri:e3d53417-1cb3-48f7-83d2-679dc1c01358
UUID:
uuid:e3d53417-1cb3-48f7-83d2-679dc1c01358
Local pid:
pubs:638966

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