Journal article
Protein inhibitor of NOS1 plays a central role in the regulation of NOS1 activity in human dilated hearts
- Abstract:
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An essential factor for the production of nitric oxide by nitric oxide synthase 1 (NOS1), major modulator of cardiac function, is the cofactor tetrahydrobiopterin (BH4). BH4 is regulated by GTP cyclohydrolase 1, the rate-limiting enzyme in BH4 biosynthesis which catalyses the formation of dihydroneopterin 3′triphosfate from GTP, producing BH4 after two further steps catalyzed by 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase. However, there are other essential factors involved ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 719.0KB)
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- Publisher copy:
- 10.1038/srep30902
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Authors
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 6
- Article number:
- 30902
- Publication date:
- 2016-08-02
- Acceptance date:
- 2016-07-08
- DOI:
- ISSN:
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2045-2322
- Source identifiers:
-
638966
Item Description
- Pubs id:
-
pubs:638966
- UUID:
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uuid:e3d53417-1cb3-48f7-83d2-679dc1c01358
- Local pid:
- pubs:638966
- Deposit date:
- 2016-08-17
Terms of use
- Copyright holder:
- Roselló-Lletí et al
- Copyright date:
- 2016
- Notes:
- This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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