Journal article
Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.
- Abstract:
-
BACKGROUND: Complex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models. METHODOLOGY/PRINCIPAL FINDINGS: We have generated extensive physiological, genetic and genome-wide gene expression profiles in a congenic strain of the spontaneously diabetic Goto-Kakizaki (GK) rat containing a large region (110 cM, 170 Mb) of rat chromosome 1 (RNO1), which covers diabetes and obesity quantitative trait loci (QTL)...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 768.6KB, Terms of use)
-
- Publisher copy:
- 10.1371/journal.pone.0002962
Authors
Funding
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PloS one More from this journal
- Volume:
- 3
- Issue:
- 8
- Article number:
- e2962
- Publication date:
- 2008-01-01
- DOI:
- EISSN:
-
1932-6203
- ISSN:
-
1932-6203
Item Description
- Language:
-
English
- Keywords:
- UUID:
-
uuid:e3be4003-91a1-49f0-a604-0fc1aab3d0c3
- Local pid:
-
pubs:17408
- Source identifiers:
-
17408
- Deposit date:
-
2012-12-19
Terms of use
- Copyright holder:
- Wallis et al
- Copyright date:
- 2008
- Notes:
- Copyright 2008 Wallis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record