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Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

Abstract:

BACKGROUND: Complex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models. METHODOLOGY/PRINCIPAL FINDINGS: We have generated extensive physiological, genetic and genome-wide gene expression profiles in a congenic strain of the spontaneously diabetic Goto-Kakizaki (GK) rat containing a large region (110 cM, 170 Mb) of rat chromosome 1 (RNO1), which covers diabetes and obesity quantitative trait loci (QTL)...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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10.1371/journal.pone.0002962

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Institution:
University of Oxford
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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
Role:
Author
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Funding agency for:
Collins, SC
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Funding agency for:
Wilder, SP
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Funding agency for:
Gauguier, D
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
3
Issue:
8
Pages:
Article: e2962
Publication date:
2008-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:e3be4003-91a1-49f0-a604-0fc1aab3d0c3
Source identifiers:
17408
Local pid:
pubs:17408

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