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Journal article

Myeloma cells down-regulate adiponectin in bone marrow adipocytes via TNF-alpha

Abstract:

Multiple myeloma is caused by abnormal plasma cells that accumulate in the bone marrow and interact with resident cells of the bone microenvironment to drive disease progression and development of an osteolytic bone disease. Bone marrow adipocytes (BMAds) are emerging as having important endocrine functions that can support myeloma cell growth and survival. However, how BMAds respond to infiltrating tumor cells remains poorly understood. Using the C57BL/KaLwRij murine model of myeloma, bone m...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/jbmr.3951

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Institution:
University of Oxford
Department:
Surgical Sciences
Role:
Author
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International Myeloma Foundation More from this funder
Publisher:
Wiley Publisher's website
Journal:
Journal of Bone and Mineral Research Journal website
Volume:
35
Issue:
5
Pages:
942-955
Publication date:
2020-01-16
Acceptance date:
2019-12-14
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
Pubs id:
pubs:1078141
UUID:
uuid:e3be2939-5a2b-4923-9393-fc97d4f734cc
Source identifiers:
1078141
Local pid:
pubs:1078141

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