Effect of concurrent zidovudine use on the resistance pathway selected by abacavir-containing regimens.

Journal article

OBJECTIVES: Abacavir (ABC) selects for four mutations (K65R, L74V, Y115F and M184V) in HIV-1 reverse transcriptase (RT), both in vitro and during monotherapy in vivo. The aim of this analysis was to compare the selection of these and other nucleoside reverse transcriptase inhibitor (NRTI)-associated mutations by ABC-containing therapies in the presence and absence of concurrent lamivudine (3TC) and/or zidovudine (ZDV) and to assess the effect of these mutations on phenotypic susceptibility t...

Expand abstract

Authors: Lanier, E; Givens, N; Stone, C; Griffin, P; Gibb, D

• Publication status: Published
• Journal: HIV medicine
• Volume: 5
• Issue: 6
• Pages: 394-399
• Publication date: 2004-11-01
• DOI: 10.1111/j.1468-1293.2004.00243.x
• EISSN: 1468-1293
• ISSN: 1464-2662
• Language: English
• Keywords: Genes, Viral; Zidovudine; Anti-HIV Agents; Retrospective Studies; Phenotype; Drug Therapy, Combination; Drug Resistance, Viral; Lamivudine; HIV Infections; Humans; HIV-1; Point Mutation; Dideoxynucleosides; Mutation; Reverse Transcriptase Inhibitors