Bisphosphonate binding affinity as assessed by inhibition of carbonated apatite dissolution in vitro.

Journal article

Bisphosphonates (BPs), which display a high affinity for calcium phosphate surfaces, are able to selectively target bone mineral, where they are potent inhibitors of osteoclast-mediated bone resorption. The dissolution of synthetic hydroxyapatite (HAP) has been used previously as a model for BP effects on natural bone mineral. The present work examines the influence of BPs on carbonated apatite (CAP), which mimics natural bone more closely than does HAP. Constant composition dissolution exper...

Expand abstract

Authors: Henneman, Z; Nancollas, G; Ebetino, F; Russell, R; Phipps, R

• Publication status: Published
• Journal: Journal of biomedical materials research. Part A
• Volume: 85
• Issue: 4
• Pages: 993-1000
• Publication date: 2008-06-01
• DOI: 10.1002/jbm.a.31599
• EISSN: 1552-4965
• ISSN: 1549-3296
• Language: English
• Keywords: Diphosphonates; Microscopy, Electron, Scanning; Temperature; Spectroscopy, Fourier Transform Infrared; Hydrogen-Ion Concentration; Bone Substitutes; Imidazoles; Apatites