Phosphorylation network dynamics in the control of cell cycle transitions.

Journal article

Fifteen years ago, it was proposed that the cell cycle in fission yeast can be driven by quantitative changes in the activity of a single protein kinase complex comprising a cyclin - namely cyclin B - and cyclin dependent kinase 1 (Cdk1). When its activity is low, Cdk1 triggers the onset of S phase; when its activity level exceeds a specific threshold, it promotes entry into mitosis. This model has redefined our understanding of the essential functional inputs that organize cell cycle progres...

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Authors: Fisher, D; Krasinska, L; Coudreuse, D; Novák, B

• Publication status: Published
• Journal: Journal of cell science
• Volume: 125
• Issue: Pt 20
• Pages: 4703-4711
• Publication date: 2012-10-01
• DOI: 10.1242/jcs.106351
• EISSN: 1477-9137
• ISSN: 0021-9533
• Language: English
• Keywords: DNA Replication; Mitosis; Phosphorylation; Saccharomyces cerevisiae; CDC2 Protein Kinase; Humans; Phosphoric Monoester Hydrolases; S Phase Cell Cycle Checkpoints; Cyclin B; Cell Cycle Checkpoints