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Journal article

A rare variant of the leptin gene has large effects on blood pressure and carotid intima-medial thickness: a study of 1428 individuals in 248 families.

Abstract:

BACKGROUND: Rare mutations in the leptin (LEP) gene cause severe obesity. Common polymorphisms of LEP have been associated with obesity, but their association with cardiovascular disease has been little studied. We have examined the impact of both common and rare polymorphisms of the LEP gene on blood pressure (BP), subclinical atherosclerosis as measured by carotid intima-medial thickness (CIMT), and body mass index (BMI) in a large family study. METHODS: Five polymorphisms spanning LEP were...

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Publication status:
Published

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Publisher copy:
10.1136/jmg.2004.027631

Authors


Gaukrodger, N More by this author
Mayosi, BM More by this author
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Journal:
Journal of medical genetics
Volume:
42
Issue:
6
Pages:
474-478
Publication date:
2005-06-05
DOI:
EISSN:
1468-6244
ISSN:
0022-2593
URN:
uuid:e399f569-eebe-4eb3-8bab-19da2a8ab4a9
Source identifiers:
104265
Local pid:
pubs:104265

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