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Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells.

Abstract:

CD28 is a major costimulatory signal receptor for T cells. We have used human naive CD4+ cells from cord blood to analyze the effect of the CD28/B7 costimulatory pathway on development of T helper (Th) subsets. We show that CD28 costimulation is critical for development of the Th2 cytokine-producing cells and that in the absence of CD28 costimulation, cells are not primed to produce Th2 cytokines and consequently "default" to the Th1 subset, independent of the presence of exogenous cytokines....

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Blood
Volume:
86
Issue:
9
Pages:
3479-3486
Publication date:
1995-11-05
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:e398b91d-fd90-4e2d-9aff-33c8383a830b
Source identifiers:
481632
Local pid:
pubs:481632

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