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Iminosugar antivirals: the therapeutic sweet spot

Abstract:

Many viruses require the host endoplasmic reticulum protein-folding machinery in order to correctly fold one or more of their glycoproteins. Iminosugars with glucose stereochemistry target the glucosidases which are key for entry into the glycoprotein folding cycle. Viral glycoproteins are thus prevented from interacting with the protein-folding machinery leading to misfolding and an antiviral effect against a wide range of different viral families. As iminosugars target host enzymes, they sh...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1042/BST20160182

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Department:
Oxford, MSD, Biochemistry
More by this author
Department:
Oxford, MSD, Biochemistry
More by this author
Department:
Oxford, MSD, Biochemistry
More by this author
Department:
Merton College
Publisher:
Portland Press Publisher's website
Journal:
Biochemical Society Transactions Journal website
Volume:
45
Issue:
2
Pages:
571-582
Publication date:
2017-04-13
Acceptance date:
2017-02-27
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
Pubs id:
pubs:689683
URN:
uri:e37adddb-f4c1-4834-982f-b8abe1f0b54e
UUID:
uuid:e37adddb-f4c1-4834-982f-b8abe1f0b54e
Local pid:
pubs:689683
Keywords:

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