Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb.

Journal article

The mechanisms by which early spatiotemporal expression patterns of transcription factors such as Pax6 regulate cortical progenitors in a region-specific manner are poorly understood. Pax6 is expressed in a gradient across the developing cortex and is essential for normal corticogenesis. We found that constitutive or conditional loss of Pax6 increases cortical progenitor proliferation by amounts that vary regionally with normal Pax6 levels. We compared the gene expression profiles of equivale...

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Authors: Mi, D; Carr, C; Georgala, P; Huang, Y; Manuel, M

• Publication status: Published
• Journal: Neuron
• Volume: 78
• Issue: 2
• Pages: 269-284
• Publication date: 2013-04-01
• DOI: 10.1016/j.neuron.2013.02.012
• EISSN: 1097-4199
• ISSN: 0896-6273
• Language: English
• Keywords: Transcription Factors; Animals; Bromodeoxyuridine; Gene Expression Regulation, Developmental; Protein Binding; Cell Proliferation; PAX7 Transcription Factor; Homeodomain Proteins; Cell Cycle; Luminescent Proteins; Cyclin-Dependent Kinase 6; Stem Cells; Mice, Transgenic; Chromatin Immunoprecipitation; Repressor Proteins; Paired Box Transcription Factors; Embryo, Mammalian; Phosphorylation; Retinoblastoma Protein; Mice; Cerebral Cortex; Eye Proteins; Body Patterning