Molecular simulation approaches to membrane proteins.

Journal article

Molecular simulations are an invaluable tool for understanding membrane proteins. Improvements to both hardware and simulation methods have allowed access to physiologically relevant timescales and have permitted the simulation of large multimeric complexes. This, coupled to the recent expansion in membrane protein structures, provides a means to elucidate the relationship between protein structure and function. In this review, we discuss the progress in using simulations to understand the co...

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Authors: Stansfeld, P; Sansom, MS

• Publication status: Published
• Journal: Structure (London, England : 1993)
• Volume: 19
• Issue: 11
• Pages: 1562-1572
• Publication date: 2011-11-01
• DOI: 10.1016/j.str.2011.10.002
• EISSN: 1878-4186
• ISSN: 0969-2126
• Language: English
• Keywords: Amino Acid Sequence; Molecular Sequence Data; Membrane Proteins; Multiprotein Complexes; Protein Binding; Molecular Dynamics Simulation; Membrane Lipids; Thermodynamics; Animals; Humans