Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration

Journal article

To differentiate the unique and overlapping functions of LFA-1 and Mac-1, LFA-1-deficient mice were developed by targeted homologous recombination in embryonic stem cells, and neutrophil function was compared in vitro and in vivo with Mac-1-deficient, CD18-deficient, and wild-type mice. LFA-1-deficient mice exhibit leukocytosis but do not develop spontaneous infections, in contrast to CD18-deficient mice. After zymosan-activated serum stimulation, LFA-1-deficient neutrophils demonstrated acti...

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Authors: Ding, Z; Babensee, J; Simon, S; Lu, H; Perrard, J

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Association of Immunologists, Inc.
• Journal: Journal of Immunology
• Volume: 163
• Issue: 9
• Pages: 5029-5038
• Publication date: 1999-11-01
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Cell Adhesion; Lymphocyte Activation; Antigens, CD18; Mice, Inbred C57BL; Female; Mice, Knockout; Stress, Mechanical; Animals; Macrophage-1 Antigen; Lymphocyte Function-Associated Antigen-1; Interphase; Injections, Subcutaneous; Chemotaxis, Leukocyte; Cell Movement; Mice; Membrane Proteins; Diffusion Chambers, Culture; Neutrophils; Male; Tumor Necrosis Factor-alpha