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The mechanisms and consequences of the extra-pulmonary dissemination of Mycobacterium tuberculosis.

Abstract:

The dissemination of Mycobacterium tuberculosis from the primary focus of infection is central to the pathogenesis of tuberculosis. Trafficking of bacteria to the regional lymph nodes is essential to the development of a protective T-cell mediated immune response, but bacteria trafficked within the bloodstream can lead to extra-pulmonary dissemination and some of the most devastating clinical consequences of tuberculosis. Yet how M. tuberculosis leaves the lungs is poorly understood. Here, we...

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Publisher copy:
10.1016/j.tube.2010.08.005

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
Journal:
Tuberculosis (Edinburgh, Scotland)
Volume:
90
Issue:
6
Pages:
361-366
Publication date:
2010-11-05
DOI:
EISSN:
1873-281X
ISSN:
1472-9792
URN:
uuid:e36209c5-9770-4859-8a7c-cedf2bf7becd
Source identifiers:
435224
Local pid:
pubs:435224

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