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Characterization of a novel subset of T cells from human spleen that lacks L-selectin.

Abstract:

Human L-selection (LAM-1, Leu-8, TQ1, DREG 56) is a member of the 'selection' family of adhesion molecules. Antibodies to L-selectin have been shown to block the binding of T cells to peripheral lymph node high endothelial venules (HEV). Most unstimulated peripheral blood T cells express high levels of L-selectin whilst it is only weakly expressed on the majority of T cells from secondary lymphoid organs. We show here (a) that T cells from tonsil and lymph node up-regulate L-selectin when rel...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Immunology
Volume:
78
Issue:
4
Pages:
623-628
Publication date:
1993-04-05
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:e3614a87-cc9b-4643-8483-3ec6cf3a4b24
Source identifiers:
35659
Local pid:
pubs:35659

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