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Exon array analysis of head and neck cancers identifies a hypoxia related splice variant of LAMA3 associated with a poor prognosis

Abstract:

The identification of alternatively spliced transcript variants specific to particular biological processes in tumours should increase our understanding of cancer. Hypoxia is an important factor in cancer biology, and associated splice variants may present new markers to help with planning treatment. A method was developed to analyse alternative splicing in exon array data, using probeset multiplicity to identify genes with changes in expression across their loci, and a combination of the spl...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pcbi.1000571

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Institute
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS Computational Biology More from this journal
Volume:
5
Issue:
11
Pages:
e1000571
Publication date:
2009-11-20
Acceptance date:
2009-10-20
DOI:
EISSN:
1553-7358
ISSN:
1553-734X

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