- Abstract:
-
Background information. CF (cystic fibrosis) is a disease caused by mutations within the CFTR (CF transmembrane conductance regulator) gene. The most common mutation, ΔF508 (deletion of Phe-508), results in a protein that is defective in folding and trafficking to the cell surface but is functional if properly localized in the plasma membrane. We have recently demonstrated that overexpression of the PDZ protein NHERF1 (Na+/H+ -exchanger regulatory factor 1) in CF airway cells induced both a r...
Expand abstract - Publisher copy:
- 10.1042/BC20070095
-
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- Journal:
- Biology of the Cell
- Volume:
- 100
- Issue:
- 7
- Pages:
- 399-412
- Publication date:
- 2008-07-05
- DOI:
- ISSN:
-
0248-4900
- URN:
-
uuid:e34dd766-1158-466f-891d-870c68b08faa
- Source identifiers:
-
238919
- Local pid:
- pubs:238919
- Copyright date:
- 2008
Journal article
β-Oestradiol rescues ΔF508CFTR functional expression in human cystic fibrosis airway CFBE41o- cells through the up-regulation of NHERF1
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