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β-Oestradiol rescues ΔF508CFTR functional expression in human cystic fibrosis airway CFBE41o- cells through the up-regulation of NHERF1

Abstract:

Background information. CF (cystic fibrosis) is a disease caused by mutations within the CFTR (CF transmembrane conductance regulator) gene. The most common mutation, ΔF508 (deletion of Phe-508), results in a protein that is defective in folding and trafficking to the cell surface but is functional if properly localized in the plasma membrane. We have recently demonstrated that overexpression of the PDZ protein NHERF1 (Na+/H+ -exchanger regulatory factor 1) in CF airway cells induced both a r...

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Publisher copy:
10.1042/BC20070095

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
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Journal:
Biology of the Cell
Volume:
100
Issue:
7
Pages:
399-412
Publication date:
2008-07-05
DOI:
ISSN:
0248-4900
URN:
uuid:e34dd766-1158-466f-891d-870c68b08faa
Source identifiers:
238919
Local pid:
pubs:238919

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