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Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling

Abstract:

The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in glucose homeostasis and food intake. GLP1R agonists (GLP1RA) are widely used in the treatment of diabetes and obesity, yet visualizing the endogenous localization, organization and dynamics of a GPCR has so far remained out of reach. In the present study, we generate mice harboring an enzyme self-label genome-edited into the endogenous Glp1r locus. We also rationally design and test various...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1038/s41467-022-35716-1

Authors


Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
14
Issue:
1
Article number:
301
Publication date:
2023-01-18
Acceptance date:
2022-12-21
DOI:
EISSN:
2041-1723
Language:
English
Keywords:
Pubs id:
1316508
Local pid:
pubs:1316508
Deposit date:
2022-12-21

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