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Dispersal of NK homeobox gene clusters in amphioxus and humans.

Abstract:

The Drosophila melanogaster genome has six physically clustered NK-related homeobox genes in just 180 kb. Here we show that the NK homeobox gene cluster was an ancient feature of bilaterian animal genomes, but has been secondarily split in chordate ancestry. The NK homeobox gene clusters of amphioxus and vertebrates are each split and dispersed at two equivalent intergenic positions. From the ancestral NK gene cluster, only the Tlx-Lbx and NK3-NK4 linkages have been retained in chordates. Thi...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0836141100

Authors


Castro, LF More by this author
Coulson, A More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
100
Issue:
9
Pages:
5292-5295
Publication date:
2003-04-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:e3452ec7-97c7-427b-8775-b315962528b8
Source identifiers:
204421
Local pid:
pubs:204421

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