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Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis.

Abstract:

Ciliary neurotrophic factor (CNTF) maintains survival of adult motor neurons. Mice lacking the CNTF gene develop mild, progressive motor neuron loss. In the normal human population, 1 to 2.3% are homozygous for a null allele, and reports suggest this mutant is associated with a younger onset of amyotrophic lateral sclerosis (ALS). We have tested this hypothesis in a study of 400 subjects with ALS and 236 controls. There was no difference in age of onset, clinical presentation, rate of progres...

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Publication status:
Published

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Publisher copy:
10.1002/ana.10638

Authors


Al-Chalabi, A More by this author
Scheffler, MD More by this author
Parton, MJ More by this author
Cudkowicz, ME More by this author
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Journal:
Annals of neurology
Volume:
54
Issue:
1
Pages:
130-134
Publication date:
2003-07-05
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
URN:
uuid:e34255ea-8541-48fd-b2f6-be374fa7307f
Source identifiers:
373957
Local pid:
pubs:373957

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