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Differential effects of D1 and D2 agonists in MPTP-treated primates: functional implications for Parkinson's disease.

Abstract:

Administration of the indirect agonist L-dopa, the nonselective direct agonist apomorphine, or the selective D2 agonist (+)-PHNO, reversed parkinsonism and induced locomotor activation in MPTP-treated squirrel monkeys. In contrast, administration of the selective partial D1 agonist SKF38393 did not induce locomotor activity, but rather decreased activity. Choreiform movements were observed only following treatment with L-dopa. Coadministration of the D1 antagonist SCH23390 prevented L-dopa-in...

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Publication status:
Published

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Publisher copy:
10.1212/wnl.40.6.927

Authors


Rupniak, NM More by this author
Steventon, MJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Neurology
Volume:
40
Issue:
6
Pages:
927-933
Publication date:
1990-06-05
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
URN:
uuid:e339a25a-e192-41c4-9daf-d662ec074922
Source identifiers:
17764
Local pid:
pubs:17764

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