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Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors.

Abstract:

OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs), in addition to their antidepressant effects, have been reported to have antiinflammatory effects. The aim of this study was to assess the antiarthritic potential of 2 SSRIs, fluoxetine and citalopram, in murine collagen-induced arthritis (CIA) and in a human ex vivo disease model of rheumatoid arthritis (RA). METHODS: Following therapeutic administration of SSRIs, paw swelling was assessed and clinical scores were determined daily i...

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Publisher copy:
10.1002/art.27304

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Journal:
Arthritis and rheumatism
Volume:
62
Issue:
3
Pages:
683-693
Publication date:
2010-03-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:e32759b6-421e-4d69-884e-0280e7df85d6
Source identifiers:
244473
Local pid:
pubs:244473

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