Journal article
Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors.
- Abstract:
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OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs), in addition to their antidepressant effects, have been reported to have antiinflammatory effects. The aim of this study was to assess the antiarthritic potential of 2 SSRIs, fluoxetine and citalopram, in murine collagen-induced arthritis (CIA) and in a human ex vivo disease model of rheumatoid arthritis (RA). METHODS: Following therapeutic administration of SSRIs, paw swelling was assessed and clinical scores were determined daily i...
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- Publisher copy:
- 10.1002/art.27304
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Authors
Bibliographic Details
- Journal:
- Arthritis and rheumatism
- Volume:
- 62
- Issue:
- 3
- Pages:
- 683-693
- Publication date:
- 2010-03-05
- DOI:
- EISSN:
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1529-0131
- ISSN:
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0004-3591
- URN:
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uuid:e32759b6-421e-4d69-884e-0280e7df85d6
- Source identifiers:
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244473
- Local pid:
- pubs:244473
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2010
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