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Clinical Clostridium difficile: clonality and pathogenicity locus diversity.

Abstract:

Clostridium difficile infection (CDI) is an important cause of mortality and morbidity in healthcare settings. The major virulence determinants are large clostridial toxins, toxin A (tcdA) and toxin B (tcdB), encoded within the pathogenicity locus (PaLoc). Isolates vary in pathogenicity from hypervirulent PCR-ribotypes 027 and 078 with high mortality, to benign non-toxigenic strains carried asymptomatically. The relative pathogenicity of most toxigenic genotypes is still unclear, but may be i...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0019993

Authors


Dingle, KE More by this author
Griffiths, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
Vaughan, A More by this author
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Journal:
PloS one
Volume:
6
Issue:
5
Pages:
e19993
Publication date:
2011
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:e32069ba-5765-40d0-b17e-8befd76ad4c2
Source identifiers:
141825
Local pid:
pubs:141825

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