Super-complexes of adhesion GPCRs and neural guidance receptors
Latrophilin adhesion-GPCRs (Lphn1-3 or ADGRL1-3) and Unc5 cell guidance receptors (Unc5A-D) interact with FLRT proteins (FLRT1-3), thereby promoting cell adhesion and repulsion, respectively. How the three proteins interact and function simultaneously is poorly understood. We show that Unc5D interacts with FLRT2 in cis, controlling cell adhesion in response to externally presented Lphn3. The ectodomains of the three proteins bind cooperatively. Crystal structures of the ternary complex formed...Expand abstract
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- Peer reviewed
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- Jackson et al.
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- This is the publisher's version of the article. The final version is available online from Nature at: [10.1038/ncomms11184].
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