Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial.

Journal article

BACKGROUND: Infection with Clostridium difficile is the primary infective cause of antibiotic-associated diarrhoea. We aimed to compare efficacy and safety of fidaxomicin and vancomycin to treat patients with C difficile infection in Europe, Canada, and the USA. METHODS: In this multicentre, double-blind, randomised, non-inferiority trial, we enrolled patients from 45 sites in Europe and 41 sites in the USA and Canada between April 19, 2007, and Dec 11, 2009. Eligible patients were aged 16 ye...

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Authors: Cornely, O; Crook, D; Esposito, R; Poirier, A; Somero, MS

• Publication status: Published
• Journal: Lancet. Infectious diseases
• Volume: 12
• Issue: 4
• Pages: 281-289
• Publication date: 2012-04-01
• DOI: 10.1016/s1473-3099(11)70374-7
• EISSN: 1474-4457
• ISSN: 1473-3099
• Language: English
• Keywords: Clostridium difficile; OPT-80-004 Clinical Study Group; Anti-Bacterial Agents; Double-Blind Method; Diarrhea; Kaplan-Meier Estimate; Female; Enterocolitis, Pseudomembranous; Aminoglycosides; Middle Aged; Feces; Prospective Studies; Vancomycin; Male; Aged; Humans