Regulation of the timing and pattern of action potential generation in rat subthalamic neurons in vitro by GABA-A IPSPs.

Journal article

The regulation of activity in the subthalamic nucleus (STN) by GABAergic inhibition from the reciprocally connected globus pallidus (GP) plays an important role in normal movement and disorders of movement. To determine the precise manner in which GABAergic synaptic input, acting at A-type receptors, influences the firing of STN neurons, we recorded the response of STN neurons to GABA-A inhibitory postsynaptic potentials (IPSPs) that were evoked by supramaximal electrical stimulation of the i...

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Authors: Bevan, MD; Magill, P; Hallworth, N; Bolam, J; Wilson, C

• Journal: Journal of neurophysiology
• Volume: 87
• Issue: 3
• Pages: 1348-1362
• Publication date: 2002-03-01
• EISSN: 1522-1598
• ISSN: 0022-3077
• Language: English
• Keywords: Animals; Rats, Sprague-Dawley; Rats; Action Potentials; Periodicity; Neural Inhibition; Neurons; Organ Culture Techniques; Male; Electric Stimulation; Receptors, GABA-A; Subthalamic Nucleus