Journal article
Cellular ageing mechanisms in osteoarthritis.
- Abstract:
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Age is the strongest independent risk factor for the development of osteoarthritis (OA) and for many years this was assumed to be due to repetitive microtrauma of the joint surface over time, the so-called 'wear and tear' arthritis. As our understanding of OA pathogenesis has become more refined, it has changed our appreciation of the role of ageing on disease. Cartilage breakdown in disease is not a passive process but one involving induction and activation of specific matrix-degrading enzym...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 749.1KB, Terms of use)
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- Publisher copy:
- 10.1007/s00335-016-9641-z
Authors
Funding
+ Kennedy Trust for Rheumatology Research
More from this funder
Funding agency for:
Sacitharan, P
Grant:
PhD Studentship
Bibliographic Details
- Publisher:
- Springer Verlag
- Journal:
- Mammalian genome : official journal of the International Mammalian Genome Society More from this journal
- Issue:
- 7-8
- Publication date:
- 2016-05-23
- Acceptance date:
- 2016-04-11
- DOI:
- ISSN:
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0938-8990 and 1432-1777
- Pmid:
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27215642
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:625425
- UUID:
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uuid:e30d8d84-7758-451e-850b-69b8b7c8e27d
- Local pid:
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pubs:625425
- Source identifiers:
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625425
- Deposit date:
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2016-09-20
Terms of use
- Copyright holder:
- Sacitharan and Vincent
- Copyright date:
- 2016
- Notes:
- © The Author(s) 2016. This article is published with open access at Springerlink.com.
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